Regional haemodynamic responses to intravenous and intraarterial endothelin-1 and big endothelin-1 in conscious rats
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چکیده
منابع مشابه
Developmental changes in Endothelin-1 and Endothelin type A receptor expression in the lungs of chickens (Broiler versus layer)
Background: Broilers lung mechanisms that regulate endothelin (ET) in the lung are complex and poorly understood. Objectives: Methods: In this experiment lung ET-1 mRNA levels and lung mRNA expression for the ET(A) receptors were determined in lung tissue weekly (term = 42 days, intervals = 7 days). Serum endothelin concentration was also measured at these ages. Results: The study showed that e...
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The extent of stroke damage in patients affects the range of subsequent pathophysiological responses that influence recovery. Here we investigate the effect of lesion size on development of new blood vessels as well as inflammation and scar formation and cellular responses within the subventricular zone (SVZ) following transient focal ischemia in rats (n = 34). Endothelin-1-induced stroke resul...
متن کاملEndothelin-1 (1-31) is an intermediate in the production of endothelin-1 after big endothelin-1 administration in vivo.
The precursor of endothelin-1, big endothelin-1, can be hydrolyzed by chymase to generate endothelin-1 (1-31) in vitro. In the present study, we explored the processes involved in the production of endothelin-1 (1-31) as well as its pharmacodynamic characteristics in the rabbit in vivo. Endothelin-1 (1-31) (1 nmol/kg, injected into the left cardiac ventricle) induced a monophasic increase of me...
متن کاملHemodynamic effects of endothelin-1 and big endothelin-1 in chronic hemodialysis patients.
Increased plasma concentrations of endothelin-1 (ET-1) and big endothelin-1 (big ET-1) have been reported in patients with end-stage renal failure (ESRD). In the present study, which included hemodialysis (HD) patients with (n = 21) and without (n = 32) ischemic heart disease, the putative association between plasma levels of ET-1 and big ET-1 and ischemic heart disease and the influence of the...
متن کاملPhosphoramidon-sensitive conversion of big endothelin-1 and degradation of endothelin-1 in rat kidney.
We investigated the intrarenal conversion of big endothelin-1 (ET-1) to ET-1 in the isolated perfused rat kidney. Big ET-1 caused a concentration-dependent increase in perfusion pressure, and the pressor molar potency of the peptide was 50-fold less than that of ET-1. The big ET-1 (2 x 10(-8) mol/L)-induced pressor action was accompanied by increases in immunoreactive endothelin levels in both ...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1993
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1993.tb13997.x